Table 2.

Effects of intravesical infusion of PD90780 on cystometric parameters

	Intravesical Infusion	Threshold Pressure, cmH2O	Micturition Pressure, cmH2O	Baseline Pressure, cmH2O	NVCs per Micturition Cycle
No CYP	PS only	15.1±0.9	38.5±1.3	15.1±0.9	0.7±0.3
	10 μM PD90780	17.0±1.3	47.1±3.0*	18.4±1.2*	1.9±0.7
	50 μM PD90780	19.4±1.1*	47.1±2.6*	21.5±1.0*	1.6±0.4
	100 μM PD90780	19.1±1.2	51.0±2.1*	21.3±1.4*	1.0±0.4
48 h CYP	PS only	19.3±0.7	46.7±1.4	20.0±0.8	0.2±0.1
	10 μM PD90780	25.1±0.8*	57.8±2.8*	24.3±0.6*	1.1±0.3*
	50 μM PD90780	25.7±0.8*	61.2±2.5*	27.7±1.3*	0.6±0.2*
	100 μM PD90780	24.0±0.8*	56.1±2.6*	24.3±0.8*	0.3±0.1

Values are means ± SE.

^*P ≤ 0.001 compared with PS (10 mg/ml) and saline infusion in control rats; n = 4–11 rats in each group. Effects of intravesical infusion of PD90780 on baseline pressure, threshold pressure, micturition pressure, and NVCs per micturition cycle are indicated. In control rats (no CYP treatment), intravesical infusion of PD90780 significantly increased micturition pressure and threshold pressure. In CYP-treated rats (48 h), PD90780 infusion significantly increased threshold pressure, micturition pressure, and NVCs.