FIG. 5.
Bisindolylmaleimide I (Bis-I), a protein kinase C (PKC) inhibitor inhibits LTH-E. A1: representative response of a Control neuron to a 2-s depolarizing current pulse on Day 1 of the experiment. A2, response of the same Control neuron in A1 on Day 2. B1: representative response to depolarizing current pulse on Day 1 of an Axotomized neuron, prior to axotomy. B2: response of the same Axotomized neuron in B1 on Day 2. C: change in number of spikes from Day 1 to Day 2 in Control and Axotomized groups. The difference between the 2 groups was not significant.