FIG. 6.
U0126, a mitogen-activated/extracellular receptor-regulated kinase (MEK) 1/2 inhibitor, does not block axotomy-induced LTH-E. A1 and A2: responses of a Control neuron on Day 1 and Day 2. There was a modest increase in the number of evoked spikes to the 2-s pulse on the second day. B1 and B2: responses of an Axotomized neuron on Day 1 and Day 2. This neuron exhibited a significant increase in its excitability on Day 2. C: change in number of evoked spikes from Day 1 to Day 2 in Control and Axotomized groups. The difference between the 2 groups was significant, as indicated by the asterisk.