FIG. 7.

U0126 blocks LTH-M due to acute axotomy. A: photomicrographs of a Control neuron on Day 1 and the same neuron on Day 2. The neuron exhibited a modest increase in the number of neuritic branches. B: photomicrographs of an Axotomized neuron on Day 1, prior to axotomy (left), the same neuron immediately after axotomy on Day 1 (0:00 h, middle), and the neuron 24 h later on Day 2 (right). Treatment with the MEK1/2 inhibitor blocked the increase in the number of branches. C: the change in the number of branch points from Day 1 to Day 2 for the Axotomized and Control groups. The difference between the Control and Axotomized groups was not significant.