TABLE 3.
Additional data from experiments involving Bis-I
| Bisindolymaleimide I | ||||||
|---|---|---|---|---|---|---|
| Parameter | Control |
Axotomized | ||||
| Day 1 | Day 2 | P | Day 1 | Day 2 | P | |
| Spike threshold, nA | 0.5 ± 0.04 | 0.5 ± 0.06 | NS | 0.5 ± 0.03 | 0.4 ± 0.03 | <0.03 |
| Membrane potential, mV | 48.2 ± 1.7 | 48.5 ± 2.0 | NS | 50.0 ± 1.1 | 49.1 ± 1.1 | NS |
| Membrane resistance, MΩ | 109.0 ± 5.3 | 100.0 ± 10.0 | NS | 103.0 ± 8.9 | 112.0 ± 6.2 | NS |
| Axonal length, μm | 284.0 ± 25.0 | 392.0 ± 40.0 | <0.004 | 272.0 ± 22.0 | 384.0 ± 38.0 | <0.002 |
There was a significant decrease in spike threshold for Axotomized, but not Control, neurons. There were no significant changes in either membrane potential or membrane resistance in the experiments. Both Control and Axotomized neurons exhibited significant increases in axonal length.