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. 2008 Oct 8;100(6):3264–3274. doi: 10.1152/jn.90418.2008

FIG. 4.

FIG. 4.

Glutamate receptor antagonist and change of holding potential during BDNF presentation confirms an absence of modulation when NMDA receptors are blocked. A: averaged time course of response to BDNF during co-application of kynurenate (n = 4 recordings). The holding potential was −40 mV, and the activity protocol was used. Block of the glutamate current during BDNF application prevented BDNF enhancement of current that was assessed following kynurenate washout. B: averaged time course of response to BDNF (n = 7 recordings). The holding potential was maintained at −80 mV except for the 2 indicated periods at −40 mV to assess the NMDA receptor component of current. As a result of changing the holding potential during these periods, the average amplitude of glutamate current increased slightly prior to BDNF perfusion and increased by a similar amount during BDNF perfusion. The data further support the conclusion that NMDA receptors are not being affected by BDNF in the absence of calcium influx.