Table 1.

Physical data of 2,3-diaryl-1,3-thiazolidin-4-one derivatives.

Comp.	Heteroaryl	R1	R2	R3	R4	MWt	% yield	m.p. °C
4a	Pyridin-2-yl		Quinolin-4-yl		H	307	75	-
4b	Pyridin-2-yl	H	NMe2	H	H	299	68	-
4c	Pyridin-2-yl	H	F	H	H	274	78	-
4d	6-methyl-pyridin-2-yl		Pyridin-3-yl		H	271	55	104–106
4e	6-methyl-pyridin-2-yl	H	NMe2	H	H	313	72	133–135
4f	Pyridin-3-ylmethyl	Cl	H	Cl	H	339	92	-
4g	4-methyl-6-trifluoromethyl-pyrimidin-2-yl	Cl	H	Cl	H	408	50	111–115
4h	4-methyl-6-trifluoromethyl-pyrimidin-2-yl	Cl	H	F	H	392	47	92–94
4i	4-methyl-6-trifluoromethyl-pyrimidin-2-yl	Br	H	Br	H	497	36	133–137
4j	4-methyl-6-phenyl-pyrimidin-2-yl	Cl	H	Cl	H	416	48	168–170
4k	4-methyl-6-phenyl-pyrimidin-2-yl	Cl	H	F	H	400	41	138–140
4l	4-phenyl-6-trifluoromethyl-pyrimidin-2-yl	Cl	H	Cl	H	470	46	206–208
4m	4,6-diphenyl-pyrimidin-2-yl	Cl	H	Cl	H	478	38	206–208
4n	4,6-diphenyl-pyrimidin-2-yl	Cl	H	F	H	462	30	176–178
4o	4,6-diphenyl-pyrimidin-2-yl	F	H	F	H	445	28	192–194
4p	Quinolin-2-yl	Cl	H	F	H	358	56	144–146
4q	Furan-2-ylmethyl	Cl	H	Cl	H	328	92	96–98
4r	Thiophen-2-ylmethyl	Br	H	Br	H	433	64	-
4s	5-ethyl-[1,3,4]-thiadiazol-2-yl	F	H	F	H	327	44	110–114
5a	Pyridin-2-yl	Cl	H	Cl	CH3	339	80	85–89
5b	Pyridin-3-ylmethyl	Cl	H	Cl	CH3	353	90	-
5c	Furan-2-ylmethyl	Cl	H	Cl	CH3	342	88	-
6	Furan-2-ylmethyl	Cl	H	Cl	H	342	90	-
7	Pyridin-2-yl		1-benzyl-piperidinyl		H	339	50	-
8a	Furan-2-ylmethyl	Cl	H	Cl	H	344	78	155–158
9	2',4'-Difluoro-4-hydroxy-biphenyl-3-carboxylic acid [2-(2-fluoro-phenyl)-4-oxo-thiazolidin-3-yl]-amide					-	-	-

^asulfoxide.