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. 2008 Dec 4;105(50):19898–19903. doi: 10.1073/pnas.0805817105

Fig. 3.

Fig. 3.

Inhibition of retinopathy by administration of DMOG in phase I of OIR. Representative flatmounts of OIR from (A) mouse injected in phase I with PBS, and (B) mouse injected in phase I with DMOG. (C) Lectin-stained tufts show new capillary buds induced by the OIR model. (Magnification: ×10.) (D) Quantitation of tortuosity, central vascular drop-out, and tufting shows a statistically significant decrease in all three vascular parameters (n = 14 animals) in DMOG-injected animals. Representative flatmounts of retinas of OIR from (E) mouse injected in phase II with PBS, and (F) mouse injected in phase II with DMOG. (G) Representative overlay that demonstrates the quantitative analysis performed on flatmounts, obtained from a masked observer using the Image-Pro version 6 program. (H) Statistical analysis demonstrates no decrease in all three vascular parameters when DMOG is injected in phase II.