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. 2008 Dec 4;105(50):19898–19903. doi: 10.1073/pnas.0805817105

Fig. 4.

Fig. 4.

Hypoxia preconditioning prevents vascular obliteration in OIR. Flatmounts of retinas at P8 hyperoxia from (A) mouse pups exposed to 6% oxygen for 24 h at P6, then subjected to 24 h hyperoxia, as well as (B) mouse pups not hypoxic preconditioned. (Magnification in A and B: Left, ×4, Right ×10.) Flatmounts of retinas at P10 (during hyperoxia) from (C) mouse pups injected with PBS on P6 (phase I) and (D) mouse pups injected with DMOG on P6 (phase I). The bar graph demonstrates the quantitative difference in capillary drop-out or avascularity between control (PBS injected) and i.p. DMOG.