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. 2008 Dec 9;105(50):20004–20008. doi: 10.1073/pnas.0810899105

Fig. 1.

Fig. 1.

The PLC inhibitor U73122 (30 mg/kg) increases pain threshold after SNI. (A) Time course of mechanical threshold measured by the von Frey hair filaments after unilateral SNI (n = 12). Ipsilateral hindpaw displays a strong and long-lasting reduction in threshold with a less pronounced decrease contralaterally. (B) Fourteen days after SNI, a single dose of U73122 causes a long-lasting, ipsilateral increase in mechanical threshold as compared with saline-treated mice (n = 6 per group). (C) The transient effects of inhibitor on mechanical threshold is also seen in the contralateral paw compared with saline-treated group 14 days after SNI (n = 6 per group). (D) Pin-prick test after SNI. (E) Cold test after SNI. The withdrawal response duration (in seconds) after nociceptive mechanical stimulation or cold stimulation (acetone) is not changed in inhibitor-treated group (n = 6) compared with saline-treated group (n = 6). Data are expressed as mean ± SEM. ***, P < 0.001; **, P < 0.01; *, P < 0.05 compared with the vehicle-treated group.