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. 2008 Dec 9;105(50):19910–19914. doi: 10.1073/pnas.0810388105

Fig. 2.

Fig. 2.

Cumulative combined, significant, and nonsignificant phenotypic effects in the survey of mouse CSSs. For each of the 41 traits that differed significantly between the parental strains, we calculated the cumulative phenotypic effect (sum across the CSSs) and the corresponding SEM. (A) Absolute value of the cumulative phenotypic effect for each trait, given in rank order. For additive interactions, the cumulative phenotypic effect should equal ≈100% (dashed horizontal line). Traits were termed “epistatic” (indicated in red) if the cumulative phenotypic effect exceeded 100% by more than the SEM. Of the 41 traits, 40 were epistatic (median cumulative effect, 803%; range, 164% to 1,397%.). (B and C) The analysis was repeated by using only those CSSs whose phenotypic difference from the host strain that achieved statistical significance (B), or fell short of statistical significance (C).