Table I.
Mitf transcriptome: genes regulated by all Mitf isoformsa
| GenBank Accession No. | Genes Up-Regulated by All Isoforms | GenBank Accession No. | Genes Up-Regulated by All Isoforms |
|---|---|---|---|
| Proteases (8) | AV231288 | N-sulfoglucosamine sulfohydrolase (sulfamidase) | |
| NM_008571# | mMCP-2 | BB829192# | Sialyltransferase 9 (CMP-NeuAc:lactosylceramide α-2,3-sialyltransferase) |
| BC026198*# | mMCP-4 | ||
| NM_010780*# | mMCP-5 | AK002700# | RIKEN clone:0610030E04 product:sulfotransferase family 1A, phenol-preferring, member 1 |
| NM_010781*# | mMCP-6 | ||
| NM_008572 | mMCP-8 | ||
| NM_012034 | Tryptase γ 1 | Chemokine/growth factor (4) | |
| NM_013542* | Granzyme B | AF065933# | Chemokine (C-C motif) ligand 2 |
| X78543# | Mus musculus MCP-Y1 mRNA, serine protease pseudogene | NM_011337 | Chemokine (C-C motif) ligand 3 |
| AF128193 | Chemokine (C-C motif) ligand 7 | ||
| Receptor/transporter (7) | NM_008808# | Platelet derived growth factor, α | |
| NM_010188 | Fc receptor, IgG, low-affinity III | Protein cross-linking (3) | |
| BC003476 | Ia-associated invariant chain | NM_028784 | Coagulation factor XIII, α subunit |
| NM_009779 | Complement component 3a receptor 1 | BC016492 | Transglutaminase 2, C polypeptide |
| BB041811 | RIKEN cDNA clone 6030458C10 3′similar to M55154 mouse transglutaminase (TGase) mRNA sequence | ||
| NM_016894# | Receptor (calcitonin) activity modifying protein 1 | ||
| X83934 | Ryanodine receptor 3 | Oxidative stress (3) | |
| NM_022026 | Aquaporin 9 | NM_008161 | Glutathione peroxidase 3 |
| NM_009303# | Synaptogyrin 1 | BC025936 | Similar to cytochrome P450, 4a10 |
| Signaling (6) | AW321975 | Mus musculus transcribed sequence with weak similarity to protein pir:A39045 protein- glutamine γ-glutamyltransferase (EC 2.3.2.13) 2, splice form 1-human | |
| NM_009192# | SLAP | ||
| NM_011299# | RSK | ||
| NM_008152# | G-protein-coupled receptor 25 | ||
| AK002933# | Neurogranin | Apoptosis (2) | |
| BC013532 | Chromatin assembly factor 1, subunit B (p60) | AF201289# | Glucocorticoid-induced leucine zipper |
| AV238793 | Apoptosis, caspase activation inhibitor | ||
| NM_026523 | Neuromedin B | Iron transport (1) | |
| Cell adhesion (6) | AF440692 | Transferrin | |
| NM_021293# | CD33 Ag | Unknown function (12) | |
| X66083 | CD44 Ag | BC002232 | Dip3 β |
| BB832194*# | Ig superfamily, member 4 (SgIGSF4) | NM_008681# | N-myc downstream regulated 1 |
| BC022734 | N-acetylneuraminate pyruvate lyase | ||
| NM_010796 | Macrophage galactose N-acetyl- galactosamine specific lectin 1 | BC027314 | DNA segment, Chr 17, human D6S56E 5 |
| BC025823 | cDNA sequence BC011467 | ||
| BM241485 | Expressed sequence AI595338 | ||
| NM_020001 | C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10 | BB026027 | RIKEN cDNA 2210023K21 gene |
| NM_133187# | RIKEN cDNA 1110032E23 gene | ||
| BC004065 | Mus musculus, clone IMAGE:3590633, mRNA, partial cds | ||
| NM_007644 | Scavenger receptor class B, member 2 | BB233088 | RIKEN cDNA clone A630041P16 3′similar to L24118 mouse primary response gene B94 mRNA, 3′end, mRNA sequence |
| Metabolism (5) | |||
| NM_016893 | Fucosyltransferase 8 | BI106458 | RIKEN clone: C130061L11 |
| AK010101# | Galactosylceramidase | BI101050 | RIKEN clone:E030018G17 product: tensin |
a
Genes were annotated with GeneSpring and EASE software, as well as visually, and grouped into functional classes.
*
Previously identified Mitf gene targets.
#
Genes that were also up-regulated in wild-type BMMC compared to Mitf−/− cells.