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. Author manuscript; available in PMC: 2009 Sep 11.
Published in final edited form as: Cell Host Microbe. 2008 Sep 11;4(3):239–248. doi: 10.1016/j.chom.2008.08.003

Figure 4. Tissue tropism is controlled by the miRNA machinery.

Figure 4

A set of five cPVR mice was infected intravenously with each engineered virus. Virus isolated from the brain (A), spinal cord (B), and spleen (C) was analyzed by a standard plaque assay six days post infection. Viral titers (PFU/ml), normalized by tissue mass, observed in the three tissues are plotted for five mice infected with each virus. Black squares designate wild type, white squares PV-L7, black circles PV-L7M, white circles PV-124, and black triangles PV-124M. In the brain and spinal cord, PV-L7 and PV-124 infected mice exhibit viral titers that are four to six orders of magnitude lower than viral titers observed in mice infected with wild type poliovirus and the control viruses, PV-L7M and PV-124M. PV-L7 viral replication is measurable in the spleen, but is still an order of magnitude lower than viral titers observed in mice infected with the other viruses. In the spleen, wild type levels are observed for PV-124 virus.