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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Gastroenterology. 2008 May 7;135(2):552–567. doi: 10.1053/j.gastro.2008.04.037

Figure 1. Development of DSS-induced chronic colitis.

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Chronic colitis induced by four cycles of DSS was evaluated and compared with untreated mice (n=7 per group). All data represent the mean ± SD. (A) Body weight as a percentage of the initial weight at day 1 are shown. (B) Colon length from cecum to rectum. (C) Tsotal numbers of mononuclear cells in GALT. (D) Cellular composition of MLN and LP cells was analyzed by flow cytometry and expressed as percentage of the whole cell population. (E) Cytokine mRNA expression was determined in MLN and colon by real-time PCR. Data were normalized to the expression of β-actin mRNA. (F) Mononuclear cells from GALT were cultured with or without anti-CD3ε and anti-CD28 Abs for IFN-γ and IL-17 and with or without LPS for IL-12 and IL-23. Cytokine productions were measured by ELISA.