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. Author manuscript; available in PMC: 2009 Aug 1.

Published in final edited form as: Gastroenterology. 2008 May 7;135(2):552–567. doi: 10.1053/j.gastro.2008.04.037

100 µg anti-mouse IL-23R mAb or control IgG were injected i.p. once per week into mice receiving DSS-drinking water (n=5 per group). (A) Body weights as percentage of initial weight at day 1. (B) Colon length and histological scores.

100 µg anti- IL-23R mAb or control IgG i.p. injections twice per week were started at day 15 (n=5 per group). (C) Body weights as percentage of initial weight at day 1 were shown. (D) Colon length and histological score. (E) Cells from MLN and LP from mice receiving control IgG, or anti-IL-23R mAb from day 15 were cultured with or without anti-CD3ε and anti-CD28 Ab for 72 h. Cytokine productions were measured by ELISA (n=5 per group).

100 µg anti-mouse IL-23R mAb or control IgG were injected i.p. once per week into mice receiving DSS-drinking water (n=5 per group). (A) Body weights as percentage of initial weight at day 1. (B) Colon length and histological scores.

100 µg anti- IL-23R mAb or control IgG i.p. injections twice per week were started at day 15 (n=5 per group). (C) Body weights as percentage of initial weight at day 1 were shown. (D) Colon length and histological score. (E) Cells from MLN and LP from mice receiving control IgG, or anti-IL-23R mAb from day 15 were cultured with or without anti-CD3ε and anti-CD28 Ab for 72 h. Cytokine productions were measured by ELISA (n=5 per group).