Table 2.
Odds ratios (OR) and 95% confidence intervals (CI) for the associations between serum pepsinogen I (PGI) and serum pepsinogen I/II ratio (PGI/II ratio) with moderate or severe esophageal squamous dysplasia
| Cases n (%) |
Controls n (%) |
Adjusted OR (95% CI)1 | |
|---|---|---|---|
| PGI | |||
| Dicohotomous | |||
| ≤ 30 ng/ml | 2 (1.6) | 4 (1.6) | 1.01 (0.18 − 5.69) |
| > 30 | 123 (98.4) | 246 (98.4) | 1.00 |
| ≤ 50 ng/ml | 9 (7.2) | 12 (4.8) | 1.70 (0.66 − 4.38) |
| > 50 | 116 (92.8) | 238 (95.2) | 1.00 |
| ≤ 100 ng/ml | 56 (44.8) | 119 (47.6) | 0.88 (0.55 − 1.39) |
| > 100 | 69 (55.2) | 131 (52.4) | 1.00 |
| ≤ 130 ng/ml | 88 (70.4) | 185 (74.0) | 0.83 (0.50 − 1.40) |
| > 130 | 37 (29.6) | 65 (26.0) | 1.00 |
| Quartiles2 | |||
| Quartile 1 (<75.4 ng/ml) | 33 (26.4) | 62 (24.8) | 0.99 (0.52−1.90) |
| Quartile 2 (75.4 −104 ng/ml) | 28 (22.4) | 63 (25.2) | 0.84 (0.44−1.60) |
| Quartile 3 (104 −132 ng/ml) | 30 (24.0) | 62 (24.8) | 0.88 (0.46−1.66) |
| Quartile 4 (>132 ng/ml) | 34 (27.2) | 63 (25.2) | 1.00 |
| Continuous decrease3 | -------- | -------- | 1.03 (0.89 − 1.18) |
| PGI/II ratio | |||
| Dichotomous | |||
| ≤ 3.0 | 6 (4.8) | 7 (2.8) | 1.80 (0.58 − 5.53) |
| > 3.0 | 119 (95.2) | 243 (97.2) | 1.00 |
| ≤ 4.0 | 9 (7.2) | 15 (6.0) | 1.17 (0.50 − 2.73) |
| > 4.0 | 116 (92.8) | 235 (94.0) | 1.00 |
| ≤ 9.0 | 73 (58.4) | 114 (45.6) | 1.88 (1.15 − 3.07) |
| > 9.0 | 52 (41.6) | 136 (54.4) | 1.00 |
| ≤ 12.0 | 99 (79.2) | 177 (70.8) | 1.78 (1.02 − 3.11) |
| > 12.0 | 26 (20.8) | 73 (29.2) | 1.00 |
| Quartiles2 | |||
| Quartile 1 (< 6.51) | 38 (30.4) | 62 (24.8) | 2.12 (1.08−4.18) |
| Quartile 2 (6.51 − 9.33) | 39 (31.2) | 63 (25.2) | 2.01 (1.02−3.96) |
| Quartile 3 (9.33 − 12.8) | 27 (21.6) | 62 (24.8) | 1.41 (0.72−2.74) |
| Quartile 4 (>12.8) | 21 (16.8) | 63 (25.2) | 1.00 |
| Continuous decrease3 | -------- | -------- | 1.22 (1.02 − 1.46) |
1
Odds ratios (ORs) and 95% confidence intervals (95% CIs) were obtained from the conditional logistic regression models adjusted for age, cigarette smoking, and place of residence.
2
Cutpoints (75th, 50th, and 25th percentiles) were 132, 104, and 75.4 ng/ml for PGI; and 12.8, 9.33, and 6.51 for PGI/II ratio.
3
Each continuous unit was equal to half the distance between the 25th and 75th percentile values in the control subjects. The units were 28.5 ng/ml for PGI and 3.13 for the PGI/II ratio.