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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Ann Neurol. 2008 Nov;64(5):485–491. doi: 10.1002/ana.21541

Fig. 4.

Fig. 4

Patterns of expression of α-synuclein mRNA in rat brain. The Figure is adapted from Maroteaux and Scheller, 1991, Figure 4. The images are darkfield micrographs of in situ hybridization for mRNA, so intense hybridization appears white on a black background. Different brain sections are arranged in ascending order according to the regions involved at different Braak Stages of synucleinopathy. In the bottom panels it is apparent that both the olfactory tubercle (LOT: nucleus of the lateral olfactory tract) and the DMN of the vagus (“10”) express high levels of α-synuclein mRNA (red arrows). In the middle panel, it can be seen that the locus ceruleus (LC) also expresses high levels. In the top panels, the amygdala (Am), and the SNpc express high levels.