Table 2.
Risk of cancer in family members of men with testicular germ-cell tumors compared with controls, overall and stratified by sex
|
All first- valign="top"> and second-degree valign="top"> relatives |
Maternal relatives |
Paternal relatives |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases |
Controls |
Cases |
Controls |
Cases |
Controls |
||||
| (592,888 person-years) |
(742,986 person-years) |
(312,495 person-years) |
(254,449 person-years) |
(227,881 person-years) |
(288,622 person-years) |
||||
|
n |
n |
RR (95% CI)* |
n |
n |
RR (95% CI)* |
n |
n |
RR (95% CI)* |
|
| All malignant neoplasms | 1,574 | 1,735 | 1.14 (1.05−1.24) | 831 | 879 | 1.16 (1.04−1.30) | 657 | 776 | 1.08 (0.95−1.21) |
| Male | 753 | 849 | 1.08 (0.97−1.21) | 329 | 349 | 1.11 (0.94−1.32) | 389 | 473 | 1.02 (0.88−1.19) |
| Female | 821 | 886 | 1.19 (1.07−1.32) | 502 | 530 | 1.20 (1.05−1.37) | 268 | 303 | 1.15 (0.97−1.37) |
| Head and neck | 46 | 68 | 0.84 (0.56−1.26) | 26 | 34 | 0.93 (0.53−1.64) | 18 | 28 | 0.79 (0.43−1.44) |
| Male | 30 | 48 | 0.76 (0.47−1.21) | 16 | 19 | 0.99 (0.49−2.01) | 13 | 25 | 0.63 (0.32−1.24) |
| Female | 16 | 20 | 1.02 (0.50−2.09) | 10 | 15 | 0.83 (0.35−2.00) | 5 | 3 | 2.13 (0.51−8.95) |
| Lung | 186 | 282 | 0.81 (0.66−1.00) | 106 | 136 | 0.93 (0.71−1.23) | 78 | 143 | 0.69 (0.51−0.94) |
| Male | 122 | 189 | 0.78 (0.62−0.99) | 63 | 85 | 0.87 (0.62−1.22) | 58 | 102 | 0.71 (0.51−0.98) |
| Female | 64 | 93 | 0.88 (0.63−1.25) | 43 | 51 | 1.07 (0.69−1.65) | 20 | 41 | 0.65 (0.37−1.15) |
| Breast | 209 | 244 | 1.09 (0.89−1.33) | 127 | 151 | 1.05 (0.82−1.36) | 77 | 85 | 1.16 (0.84−1.61) |
| Digestive tract | 223 | 213 | 1.29 (1.06−1.58) | 127 | 101 | 1.52 (1.15−2.00) | 94 | 108 | 1.09 (0.81−1.46) |
| Male | 111 | 119 | 1.13 (0.87−1.47) | 54 | 46 | 1.36 (0.92−2.03) | 55 | 70 | 0.96 (0.67−1.40) |
| Female | 112 | 94 | 1.50 (1.13−2.00) | 73 | 55 | 1.65 (1.15−2.37) | 39 | 38 | 1.32 (0.84−2.08) |
| Urinary system | 42 | 48 | 1.09 (0.71−1.67) | 26 | 27 | 1.16 (0.66−2.04) | 15 | 19 | 1.04 (0.53−2.05) |
| Male | 31 | 29 | 1.32 (0.80−2.20) | 18 | 13 | 1.66 (0.80−3.42) | 12 | 14 | 1.13 (0.52−2.43) |
| Female | 11 | 19 | 0.72 (0.34−1.53) | 8 | 14 | 0.68 (0.28−1.64) | 3 | 5 | 0.79 (0.18−3.38) |
| Hematopoetic | 86 | 86 | 1.25 (0.90−1.72) | 47 | 39 | 1.50 (0.96−2.34) | 31 | 43 | 0.89 (0.55−1.44) |
| Male | 44 | 53 | 1.02 (0.67−1.56) | 23 | 18 | 1.52 (0.79−2.90) | 16 | 33 | 0.60 (0.33−1.09) |
| Female | 42 | 33 | 1.61 (1.02−2.56) | 24 | 21 | 1.47 (0.81−2.66) | 15 | 10 | 1.83 (0.79−4.22) |
| Male genital organs | 175 | 144 | 1.52 (1.19−1.94) | 70 | 50 | 1.70 (1.15−2.51) | 94 | 91 | 1.30 (0.94−1.80) |
| Testis | 28 | 12 | 3.03 (1.47−6.21) | 12 | 4 | 3.85 (1.22−12.12) | 5 | 5 | 1.34 (0.38−4.78) |
| Prostate | 146 | 130 | 1.39 (1.07−1.81) | 58 | 46 | 1.52 (1.00−2.32) | 88 | 84 | 1.32 (0.94−1.84) |
| Female genital organs | 132 | 132 | 1.27 (0.98−1.65) | 85 | 82 | 1.29 (0.95−1.74) | 22 | 26 | 1.07 (0.59−1.94) |
| Melanoma skin | 29 | 40 | 0.94 (0.57−1.55) | 16 | 25 | 0.80 (0.42−1.52) | 8 | 11 | 0.95 (0.37−2.45) |
| Male | 13 | 22 | 0.75 (0.37−1.52) | 4 | 12 | 0.41 (0.13−1.25) | 6 | 8 | 0.97 (0.31−2.98) |
| Female | 16 | 18 | 1.34 (1.01−1.77) | 12 | 13 | 1.19 (0.53−2.63) | 2 | 3 | 0.91 (0.16−5.27) |
| Non-melanoma skin | 184 | 169 | 1.40 (1.10−1.77) | 92 | 85 | 1.35 (0.96−1.91) | 79 | 73 | 1.41 (0.99−1.99) |
| Male | 109 | 102 | 1.17 (0.59−2.31) | 38 | 35 | 1.31 (0.79−2.18) | 62 | 62 | 1.29 (0.90−1.84) |
| Female | 75 | 67 | 1.49 (1.04−2.11) | 54 | 50 | 1.39 (0.92−2.10) | 17 | 11 | 2.20 (0.98−4.93) |
*
Adjusted for reference age and race/ethnicity of cases/controls, sex (for non-sex-stratified analyses), and side of family (for analyses of all first- and second-degree relatives)