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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Nat Chem Biol. 2008 Nov 23;5(1):37–44. doi: 10.1038/nchembio.129

Fig. 5.

Fig. 5

Time course analysis of inhibitory activity of JZL184 in vivo. a and b, Serine hydrolase activity profiles (a) and MAGL and FAAH activities (b) of brain membranes prepared from mice treated with JZL184 (16 mg kg-1, i.p.) for the indicated times. c-e, Brain levels of 2-AG (c), arachidonic acid (d), and AEA (e) from mice treated with JZL184 (16 mg kg-1, i.p.) for the indicated times. For b-e, *, p < 0.05; **, p < 0.01 for inhibitor-treated versus vehicle-treated control animals. Data are presented as means ± SEM. n = 3-5 mice per group.