Skip to main content
. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Nat Chem Biol. 2008 Nov 23;5(1):37–44. doi: 10.1038/nchembio.129

Fig. 6.

Fig. 6

Behavioral effects of JZL184. a-d, JZL184 produced antinociceptive effects in the tail immersion assay of thermal pain sensation (a; 16 mg kg-1, i.p.), acetic acid abdominal stretching assay of noxious chemical pain sensation (b; 16 mg kg-1, i.p.), and both phase 1 (c; 40 mg kg-1, p.o.) and phase 2 (d; 40 mg kg-1, p.o.) of the formalin test. These effects were blocked by pre-treatment with the CB1 antagonist rimonabant (Rim., 3 mg kg-1). JZL184 (16 mg kg-1 i.p.) also produced significant hypothermia (e) and hypomotility (f) that were significantly attenuated by rimonabant. The baseline tail immersion latency and rectal temperature was 0.82 ± 0.02 s and 37.4 ± 0.1°C, respectively. *, p < 0.05; **, p < 0.01, for vehicle-vehicle versus vehicle-JZL184-treated mice. #, p < 0.05; ##, p < 0.01, for vehicle-JZL184 versus rimonabant-JZL184-treated mice. Data are presented as means ± SEM. n = 6-14 mice per group.