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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Cell Death Differ. 2008 Oct 10;16(1):175–183. doi: 10.1038/cdd.2008.143

Figure 1. DT-EGF kills glioblastoma and epithelial tumor cells by different mechanisms.

Figure 1

Panel A, quantification of clonogenic growth assay after treatment of HeLa, HN12, U87MG and U373MG cells for 24 hours with increasing doses of DT-EGF. All the cell lines die with similar dose responses (mean +/- SD from three experiments). Panel B shows frames from time-lapse movies of DT-EGF-treated HeLa cells and U87MG cells, showing that the morphological characteristics of the dying cells differs with only the epithelial cells displaying characteristics of apoptosis. Panel C, western analysis of PARP cleavage after 24 hours of DT-EGF treatment. Only the epithelial cells contain caspase-cleaved PARP.