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. Author manuscript; available in PMC: 2009 Jun 11.
Published in final edited form as: Nature. 2008 Nov 9;456(7223):809–813. doi: 10.1038/nature07424

Figure 2. VEGF Disrupts Pericyte Coverage/VSMC Activation through VEGF-R2.

Figure 2

a, Right: confocal microscopy images of reconstituted basement membrane impregnated with growth factors from mice perfused with fluorescent Griffonia lectin (green), stained for α-SMA (red). Left: pericyte coverage as assessed by α-SMA/lectin co-localization; *P<0.01, results from one-way ANOVA, n=6/group. b, Representative proliferation (upper, *P<0.001) and migration assays (lower, *P<0.001); *results from one-way ANOVA. c, Representative VSMC proliferation (upper, *P<0.01; **P<0.05) and migration (lower, *P<0.001, **P<0.001) assays performed after siRNA-mediated knock-down of VEGF receptors normalized to PBS control where indicated; results from one-way ANOVA, n>3 experiments. All error bars ± S.D.