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. Author manuscript; available in PMC: 2009 Jun 11.
Published in final edited form as: Nature. 2008 Nov 9;456(7223):809–813. doi: 10.1038/nature07424

Figure 4. VEGF Loss Attenuates VEGF-R2/PDGF-Rβ Complex Formation and Tumor Vessel Maturation.

Figure 4

a, Confocal microscopy of WT (VEGF+/+) and KO (VEGF−/−) fibrosarcomas demonstrating histological markers of vascular maturity and phosphorylated PDGF-Rβ (Y751) with b, image analysis; P<*0.01, **P<0.001, ***P<0.05, results from unpaired t-test, n>3 animals/group. c, anti-PDGF-Rβ immunoprecipitated tumor lysates derived from VEGF+/+ and VEGF−/− tumors.