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Normal nociception in TIP39-KO
| Test | WT | KO |
|---|---|---|
| von Frey (g) | 4.1 ± 1.1 | 4.5 ± 0.9 |
| Tail-flick latency (seconds) | 4.0 ± 0.7 | 3.9 ± 0.2 |
| Hotplate latency (seconds) | 8.0 ± 0.6 | 9.6 ± 0.9 |
| Hargreaves latency (seconds) | 4.7 ± 0.6 | 4.2 ± 0.4 |
TIP39-KO did not differ from WT in mechanical sensitivity tested with von Frey fibers or in thermal sensitivity evaluated in the tail-flick, hotplate and Hargreaves tests. Data are mean ± SEM and n = 10/genotype for each test.
