Table 4.

Multivariate Model of Death from Locally Recurrent Disease for Patients Age ≥ 16 with Low Grade Soft Tissue Sarcoma Resected with Curative Intent

Variable*	Hazard Ratio for Death from Soft Tissue Sarcoma (95% Confidence Interval)
Primary Site**
Extremity	1.00 (referent)
Trunk	5.98 (1.01 – 35.48)
Other¶	19.80 (4.26 – 92.10)
Visceral†	16.09 (2.86 – 90.62)
Retroperitoneal	59.10 (13.22 – 264.32)
Primary Tumor Size
≤ 5 cm	1.00 (referent)
> 5 cm ≤ 10 cm	6.78 (1.98 – 23.14)
> 10 cm	10.23 (3.06 – 34.27)
Histology
Other¶¶	1.00 (referent)
Malignant Fibrous	1.05 (0.32 – 3.48)
Histiocytoma (MFH)
Leiomyosarcoma	2.14 (0.73 – 6.27)
Liposarcoma	1.87 (1.08 – 3.25)
Margin Status
R0	1.00 (referent)
R1	2.26 (1.40 – 3.68)
R2	5.86 (3.42 – 10.04)

^*Variables significant at the 0.10 level on univariate analysis were included in the multivariate model. Gender, depth, and age were not statistically significant variables on multivariate analysis. Treatment-related variables were not included in the multivariate model since their association with the outcome of interest could not be assumed to be independent.

^**Although there were significant differences in DOLR by primary tumor site, multivariate analysis demonstrated liposarcoma histology to be a more reliable predictor of DOLR than site, likely because site and histology are tightly linked covariables.

^¶Includes thoracic, head and neck, and skin.

^†Includes gastrointestinal, gynecologic, and genitourinary.

^¶¶Includes all histologies except MFH, leiomyosarcoma, and liposarcoma.