Table 5.

Multivariate Model of Death from Distant Metastatic Disease for Patients Age ≥ 16 with Low Grade Soft Tissue Sarcoma Resected with Curative Intent

Variable*	Hazard Ratio for Death from Soft Tissue Sarcoma (95% Confidence Interval)
Primary Tumor Size
≤ 5 cm	1.00 (referent)
> 5 cm ≤ 10 cm	3.54 (1.50 – 8.36)
> 10 cm	3.24 (1.34 – 7.85)
Local Recurrence¶
No	1.00 (referent)
Yes	1.90 (1.26 – 2.87)

^*Variables significant at the 0.10 level on univariate analysis were included in the multivariate model. Gender, depth, age, histologic subtype, primary tumor site, and margin status at initial operation were not statistically significant variables on multivariate analysis. Treatment-related variables were not included in the multivariate model since their association with the outcome of interest could not be assumed to be independent.

^¶The association between local recurrence and DODR was tested using landmark analysis since a local recurrence cannot be considered a baseline variable.