Table 4.
Genomic imbalances in the zebrafish melanoma model observed in multiple fish.
| BAC Clonea | LG Chromosome Assignment by FISH | Relative Position Along Chromosome | Initial Designation of BAC Clone (Marker/Oncogene/TSG)b | Current Gene Annotation (Nov. 2007) | No. of Samples with a Significant Genomic Imbalance (N = 6) | Percent of Samples with a Significant Genomic Imbalance | Gain/Loss |
|---|---|---|---|---|---|---|---|
| zK031B10 | 2 | 6.5 | Oncogene | PRKCI | 2 | 33% | Gain |
| SKIL | |||||||
| SLC24A6 | |||||||
| zK021H14 | 4 | 2 | Oncogene | DMBT1 | 2 | 33% | Loss |
| zK222F08 | 4 | 2.5 | Oncogene | BRAF | 2 | 33% | Loss |
| BTBD11 | |||||||
| CRY1 | |||||||
| MRPS33 | |||||||
| TNNT2 | |||||||
| zC239E06 | 4 | 2.5 | TSG | CDKN1B | 3 | 50% | Loss |
| PPARA | |||||||
| WNT7B | |||||||
| zC079A18 | 4 | 9 | Marker | ZDB-GENE- | 2 | 33% | Loss |
| 060503-161 | |||||||
| ZDB-GENE- | |||||||
| 060503-255 | |||||||
| ZDB-GENE- | |||||||
| 060503-433 | |||||||
| zK255N06 | 16 | 8 | Oncogene | ALKBH8 | 3 | 50% | Loss |
| DYRK1A | |||||||
| FBL | |||||||
| KCNJ5 | |||||||
| zC143E20 | 19 | 4.5 | Oncogene | MYCL1 | 3 | 50% | Gain |
| TRIT1 | |||||||
| zK219L12 | 19 | 4.5 | Marker | IRX1 | 2 | 33% | Gain |
| PEG10 | |||||||
| zC194E15 | 19 | 8 | Oncogene | KIAA1522 | 3 | 50% | Gain |
| MFSD2 | |||||||
| MYCL1 | |||||||
| TRIT1 | |||||||
| YARS | |||||||
| zK201G07 | 19 | 9 | TSG | ANP32E | 2 | 33% | Gain |
| PLEKHO1 | |||||||
| POGZ | |||||||
| PSMB4 | |||||||
| RDH13 | |||||||
| SUHW4 | |||||||
| VPS45 | |||||||
| zK023K06 | 20 | 4 | Oncogene | EPHA7 | 2 | 33% | Gain |
| ZNF452 | |||||||
| zC171D11 | 22 | 4.5 | TSG | AK097143 | 3 | 50% | Gain |
| EPS15L1 | |||||||
| KIAA1509 | |||||||
| KLF2 | |||||||
| RC3H1 | |||||||
| STIL | |||||||
| zC206A19 | 22 | 4.5 | Marker | MIER2 | 2 | 33% | Gain |
| PPAP2C | |||||||
| TLE1 | |||||||
| ZBED5 | |||||||
| zC197G15 | 22 | 5 | Oncogene | GPR52 | 3 | 50% | Gain |
| HNRPM | |||||||
| IFI44L | |||||||
| MARCH2 | |||||||
| PIP5K1C | |||||||
| RAB11B | |||||||
| RABGAP1L | |||||||
| zK192M14 | 22 | 8.5 | TSG | EDG1 | 2 | 33% | Gain |
| EPS15L1 | |||||||
| KLF2 | |||||||
| RC3H1 | |||||||
| SERPINC1 | |||||||
| STIL | |||||||
| ZBTB37 | |||||||
| zC195I16 | 23 | 3.5 | Oncogene | C20orf11 | 3 | 50% | Gain |
| DNAJC5 | |||||||
| FYN | |||||||
| HRIHFB2255 | |||||||
| NOL4 | |||||||
| TPD52L2 | |||||||
| TRIM54 | |||||||
| TRIM55 | |||||||
| zC226M16 | 23 | 4 | Marker | FLJ20489 | 2 | 33% | Gain |
| MUC3 | |||||||
| zK151G10 | 23 | 5 | Oncogene | ERBB3 | 2 | 33% | Gain |
| FAM62A | |||||||
| PA2G4 | |||||||
| WNK3 |
a
zC denotes the CHORI-211 zebrafish BAC clone library and zK denotes the Danio Key zebrafish BAC clone library
b
Please see Table S1 for original gene annotation