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. 2008 Dec 22;205(13):3091–3103. doi: 10.1084/jem.20081163

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© 2008 Murn et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 3. — Ptger4 is a candidate tumor suppressor in B cells. (A) Stable A20 cell lines were generated by lentiviral infection as described in Materials and methods. Ptger4 expression was determined by qPCR and confirmed by Western blotting. (B) ATP content and viability of stable P493-6 cell lines in culture. RLU, relative luminescence units. Error bars are the SD of triplicates. (C) Survival of BALB/c mice injected with 2 × 10⁵ A20 cells stably expressing the indicated constructs. 10 mice were used to derive each survival curve. Logrank test comparing two survival curves was used to derive P values, as indicated. (D) Tumor formation at the site of injection of the indicated stable A20 cell line at 20 d after injection (5 × 10⁵ cells were injected per mouse; top), and a fluorescence micrograph showing GFP-expressing tumor tissue in the eye region (bottom).