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. 2008 Dec 22;205(13):3091–3103. doi: 10.1084/jem.20081163

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© 2008 Murn et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 6. — MYC down-regulates the expression of PTGER4 in human B cell lymphoma. (A) PTGER4 is significantly down-regulated in human DLBCL cells relative to normal B cells. Data were analyzed from reference 30. The P value from Wilcoxon rank sum test is shown. (B) MYC inhibits BCR-triggered induction of PTGER4 in the human P493-6 B cell line. Cells were incubated with (Tet ON) or without Tet (Tet OFF) for 3 d, and the expression of PTGER4 after BCR-triggering was determined by qPCR. Tet-dependent MYC expression is shown in the insert. Error bars are s.d. of triplicates. (C) PTGER4 and several known tumor suppressors are coordinately down-regulated in multiple human B cell lymphomas with MYC translocation (38). Data were analyzed from a comprehensive study, including samples of 220 mature aggressive B cell lymphomas using the algorithm of the human cancer-profiling database Oncomine (see URLs in Materials and methods) (57). Shown is the heat map comprising the microarray results, where red indicates induction of genes and blue indicates repression of genes. Samples were classified according to the presence (or absence) of MYC translocations, as indicated. Genes showing the lowest P values were selected and ranked in ascending order. The selected genes, except PTGER4, have been described as tumor suppressors in B cell lymphoma according to Pubmed (see URLs in Materials and methods). The scheme om the bottom presents the interaction between MYC and PTGER4 in a lymphoma-relevant context.