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. 2008 Dec 22;205(13):2985–2994. doi: 10.1084/jem.20082053

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© 2008 Panigrahi et al.

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Figure 4. — Autoimmune-prone mouse strains display reduced levels of RS rearrangement. (a) Vκ-RS rearrangement levels in bone marrow subsets of MRL/lpr mice (white bars; n = 4) and NOD mice (gray bars; n = 5). Data from C57BL/6 mice are included for comparison. (b) Vκ-RS rearrangement levels in κ⁺ splenic B cell subsets from C57BL/6 (black bars; n = 5), MRL/lpr (white bars; n = 4), and NOD (gray bars; n = 5) mice. All PCR reactions were performed in duplicate. Data are represented as fold difference (+SEM; *, P < 0.05 and **, P < 0.01) relative to the mean RS level in C57BL/6 splenic B220⁺ IgM⁺ κ⁺ B cells (dashed lines).

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