Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Dec 22;205(13):2975–2984. doi: 10.1084/jem.20081800

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2008 Orešič et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 2. — Selected autoantibody and metabolite changes during the prediabetic period in a girl who progressed to type 1 diabetes at close to 9 yr of age (HLA-haplotype DR7-DQ2/DR4-DQ8, moderate genetic risk). (A) GADA and IAA profiles. The relative autoantibody level values are calculated as the ratio of their measured levels and corresponding cutoff limits for autoantibody positivity. Scales are linear and adjusted separately for each autoantibody for clarity. Time of seroconversion to positivity for each autoantibody is marked, as is the time of diagnosis of type 1 diabetes. The child also seroconverted to ICA and IA-2A autoantibody positivity within 6 mo before the appearance of IAA. (B) Changes of ketoleucine, leucine, lysoPC (the profile shown is for the most abundant lysoPC species PC(18:0/0:0)), and ether PC (the profile shown is for the most abundant ether PC species PC(O-18:1/20:4)) with age. Fold changes are calculated as ratios of metabolite level at a given time point and the normal level, i.e., the mean value across all samples in the nonprogressors. Scales are linear and adjusted separately for each metabolite for clarity. (C) The changes of glutamic acid, GABA, α-ketoglutarate (α-KG), and glutamine with age.