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. 2008 Dec 22;205(13):2975–2984. doi: 10.1084/jem.20081800

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© 2008 Orešič et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 4. — Comparison of serum metabolomes between progressors to type 1 diabetes and nonprogressors who remained autoantibody negative throughout the follow up. The age groups are divided into birth (cord blood) and then into groups covering 1-yr periods of followup. Only one sample per subject, closest to the mean age within the time window (0.5, 1.5, 2.5 yr, etc.), is used in each comparison. Clustering was performed for the profiles across all available samples (n = 419) using Ward linkage and the nonparametric Spearman rank correlation–based distance metric. The number of subjects included in each age cohort is shown at the bottom.