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. 2008 Dec 22;205(13):2975–2984. doi: 10.1084/jem.20081800

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© 2008 Orešič et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — Selected metabolite differences between progressors and nonprogressors within 18-mo periods before and after seroconversion to islet autoantibody positivity, divided into four 9-mo periods. (A) Illustrative matching of progressors and nonprogressors for studies of seroconversion-related changes in metabolome. For each progressor's samples near the selected period of seroconversion, the age-matched control samples were selected from the matched nonprogressor. (B) Changes before (Ab⁻) and after (Ab⁺) first seroconversion to islet autoantibody positivity. Only one sample from each subject, closest to the time of seroconversion, is included within each time period. Clustering was performed as described in Fig. 4. (C) Changes before and after seroconversion to positivity for each autoantibody. Only one sample from each subject, closest to the time of seroconversion, is included within each time period. Lipids were measured in 56 progressors and 73 nonprogressors, whereas the metabolites were measured in 13 progressors and 26 nonprogressors as shown in Table S1.