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. 2008 Dec 30;3(12):e4066. doi: 10.1371/journal.pone.0004066

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Mine et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Preferential modifications of Fp characteristics throughout aging may have structural and physiological consequences not only on the dermis, but also on the epidermis. Cellular differentiation of epidermal keratinocytes and dermal fibroblasts may be symmetrically organized including upward differentiation of keratinocytes associated with downward differentiation of fibroblasts. This cellular organization may be altered during skin aging.