Table 1. Secretion profiles of cytokines, MMPs and TIMPs by Fp and Fr as a function of donor's age.
| Category | Specific proteins | Fibroblasts and ratio | R | p-value | Regulation |
| Cytokines | KGF | Fp | *0.599 | *0.014 | Up-regulation |
| Fr | 0.075 | 0.782 | No regulation | ||
| Fr/Fp | *0.657 | *0.006 | |||
| VEGF | Fp | 0.38907 | 0.1364 | Up-regulation | |
| Fr | 0.105 | 0.698 | No regulation | ||
| Fr/Fp | 0.41096 | 0.1138 | |||
| IL-6 | Fp | 0.162 | 0.55 | No regulation | |
| Fr | 0.04 | 0.883 | No regulation | ||
| Fr/Fp | 0.114 | 0.674 | |||
| MCP-1 | Fp | 0.176 | 0.515 | No regulation | |
| Fr | *0.514 | *0.042 | Down-reguation | ||
| Fr/Fp | *0.615 | *0.011 | |||
| MMPs | MMP-1 | Fp | *0.531 | *0.034 | Up-regulation |
| Fr | 0.258 | 0.335 | No regulation | ||
| Fr/Fp | *0.690 | *0.003 | |||
| MMP-2 | Fp | *0.533 | *0.034 | Up-regulation | |
| Fr | 0.158 | 0.559 | No regulation | ||
| Fr/Fp | 0.479 | 0.0601 | |||
| MMP-3 | Fp | *0.527 | *0.036 | Up-regulation | |
| Fr | 0.095 | 0.726 | No regulation | ||
| Fr/Fp | *0.686 | *0.003 | |||
| TIMPs | TIMP-1 | Fp | *0.622 | *0.010 | Up-regulation |
| Fr | 0.096 | 0.724 | No regulation | ||
| Fr/Fp | *0.609 | *0.012 | |||
| TIMP-2 | Fp | *0.536 | *0.032 | Up-regulation | |
| Fr | 0.098 | 0.719 | No regulation | ||
| Fr/Fp | 0.451 | 0.079 |
Evolution with age of the secretion profiles of Fp and Fr was analyzed by linear regression on a cohort of 16 different pairs of fibroblast samples obtained from independent donors, ranging from 19 to 74 years old. Secretion level of specific proteins was considered as significantly modulated with age when the correlation coefficient (R) was found >0.5 (in absolute value) and p<0.05 (*).