Figure 5.

A, B – Main-effect of face > building (first slice) and building > face (second slice) stimuli in control (A) and AD (B) subjects on placebo. The slices chosen include regions which additionally show interactions with task, treatment and group as illustrated below. Regions shown for face-selectivity are bilateral posterior STS (z = +12); and for building-selectivity are lateral occipital and retrosplenial cortices (z = +2).

C, D, E – Interaction of stimulus-selectivity × task in controls (C), AD (D) and the difference between them (E) on placebo: regions shown are those in which Age relative to Color task results in greater face-versus-building (first slice) and building-versus-face (second slice) responses.

F, G, H – Interaction of stimulus-selectivity × task × treatment in controls (F), AD (G) and the difference between them (H): circled regions are those in which task-enhancements of face- and building- selectivity are decreased by physostigmine relative to placebo in controls (F) but increased by physostigmine relative to placebo in AD (G).

I – Interaction of stimulus-selectivity (face > building) × task in controls (first slice) and AD (second slice); region circled shows greater task task-modulation of stimulus-selectivity in AD relative to controls, that itself is cholinergic dependent (z = +8; see text).

J – Plots of %-signal change for face > building (first and third graphs) and building > face (second graph) contrasts, under each task, treatment and group at the maxima for the 4-way interaction (from H; first two graphs) and at the maximum task × stimulus interaction in AD (from I; third graph).

Activations are thresholded at p<0.001, uncorrected, except for F and G that are thresholded at p<0.01, uncorrected, and are superimposed on the mean normalised EPI of controls or patients as appropriate (group interactions are overlaid on patients' mean).