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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: J Clin Neurosci. 2008 Sep 23;15(11):1264–1269. doi: 10.1016/j.jocn.2007.11.007

Table 1.

After exposure to various intravenous anesthetics for 30 minutes, median effective concentrations (EC50) were calculated for labeled norepinephrine ([3H]-NE) uptake in human embryonic kidney 293 cells transfected with the cDNA of norepinephrine (HEK-hNET) and labeled 5-hydroxytryptamine ([3H]-5-HT) uptake in HEK cells transfected with the cDNA of serotonin transporter (HEK-hSERT).

Treatment EC50 of [3H]-NE uptake in HEK-
hNET cells		 EC50 of [3H]-5-HT uptake in
HEK-hSERT cells
Without
desipramine		 With
desipramine		 Without
fluoxetine		 With
Fluoxetine
Propofol 41.9 μM 1.5 μM 101.3 μM 4.9 μM
Ketamine 290.7 μM 1670 μM 125.2 μM 2253 μM
Etomidate > 50 mM NA >50 mM NA
Thiopental > 50 mM NA >50 mM NA

NA = not applicable