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This work used the SAMDI mass spectrometry method to assay the activities of histone deacetylase enzymes. (A) The monoacetylated peptide, Ac-GAKRHRKAcVC-NH2, is immobilized to a monolayer presenting a maleimide group and then treated with HDAC8 to give the deacetylated peptide. (B) The SAMDI spectrum shows a shift of m/z 42, indicating the loss of an acetyl group.
