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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: J Immunol. 2008 May 1;180(9):6077–6084. doi: 10.4049/jimmunol.180.9.6077

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Anti-CD154 plus DST induces dominant allograft tolerance in BALB/c recipients of C57BL/6 heart grafts. (a) Long-term graft survival following treatment with anti-CD154/DST (N=7 for non-tolerant; N≥42 for anti-CD154/DST). (b) Tolerant BALB/c mice accept donor-specific C57BL/6 and F1 (C3H x C57BL/6), but not third-party C3H heart grafts, transplanted on ≥60 days post-first heart transplantation (N=6-8/group) (c) Infectious tolerance is illustrated by the ability of tolerant spleen cells to prevent rejection by naïve/non-tolerant spleen cells (20 × 106/mouse) when administered at a 1:4 (naïve/non-tolerant:tolerant) ratio with tolerant spleen cells into BALB/c-scid mice transplanted with a C57BL/6 heart graft (N=4/group).