Chronic rejection. a, A small hepatic artery branch in a graft, OT 16b, 339 days after retransplantation is almost occluded by intimal thickening. Elastic stain, ×60. b, Residual scarring after rejection. Same graft, OT 16b. There is increased portal fibrous tissue and connective tissue septums extend into the lobules. Reticulin, ×60. c, Centrilobular cholestasis with bile “thrombi” in dilated canaliculi in graft, OT 14a, one year and 16 days after transplantation. Bile stain, ×200. d, Collapse of reticulin fiber framework around central veins in graft, OT 10, 186 days after transplantation. Reticulin, ×60.