Effect of BQ123 on resting capillary blood cell velocity (CBV) (a) and peak capillary blood cell velocity following a 1-min arterial occlusion (b) in patients with type 2 diabetes (n = 10) and nondiabetic controls (n = 8). Data are shown as the mean and SEM. A significant difference between groups in the change in resting CBV and peak CBV, respectively, following a 60-min infusion of BQ123 is shown. Copyright © 2008. Reproduced with the kind permission of Karger AG, Basel from Settergren M, Pernow J, Brismar K, et al 2008. Endothelin-A receptor blockade improves nutritive skin capillary circulation in patients with type 2 diabetes and albuminuria. J Vasc Res, 45:295–302.