Fig. 7.

Bar graphs summarizing total remyelination (A) and percent restoration of intact myelination levels (B) observed under many different transplant protocols. (See Materials and Methods for formulas.) Note that transplantation of Schwann cell from donors of any age, with or without ONA co-transplantation, resulted in an increase in both total remyelination and percentage of myelin restoration. Both total remyelination (M_re,Total) and percent myelin restoration (M_restore) for all Schwann cell-transplanted lesions differ significantly from DMEM-only controls and ONA-transplanted lesions at P < 0.000001 and P < 0.001, respectively (unpaired Student’s t-test). Percent myelin restoration in ONA-only transplant lesions was also increased over DMEM controls at P < 0.06, and total remyelination and percent myelin restoration for each individual cell transplantation protocol, represented by more than two experiments, were increased over controls at P < 0.03 or better (unpaired Student’s t-test). See Figure 4 for or Table 1 for N values. For abbreviations, see list.