Table 6. Haplotype analysis of LOXL1 SNPs in POAG in the Beijing cohort.
| Haplotype | rs1048661 | rs3825942 | rs2165241 |
Haplotype frequency |
HS test (df=1) |
|
|---|---|---|---|---|---|---|
| POAG | Controls | p value | ||||
| B1 |
T |
G |
C |
0.521 |
0.503 |
0.612 |
| B2 |
G |
G |
C |
0.298 |
0.279 |
0.578 |
| B3 |
G |
A |
C |
0.098 |
0.135 |
0.117 |
| B4 |
G |
G |
T |
0.083 |
0.084 |
0.982 |
| B5 | T | G | T | - | - | - |
The B5 haplotype, although not detected in the Beijing cohort, was listed in the table to make a comparison with the Hong Kong cohort in Table 5. The SVH test was not done in the Beijing cohort because of the non-significant omnibus association. Omnibus X2=2.525 (df=3); p=0.471. n=169 case and n=197 control subjects.