Table 7. Summary of the reported allele frequencies of the LOXL1 polymorphisms in POAG.
Population | Phenotype |
Allele Frequency |
Sample Size | Reference | ||
---|---|---|---|---|---|---|
rs1048661 G | rs3825942 G | rs2165241 T | ||||
Iceland |
Control |
0.651 |
0.847 |
0.473 |
14474 |
[21] |
|
POAG |
0.711 |
0.872 |
0.55 |
90 |
|
Sweden |
Control |
0.682 |
0.879 |
0.535 |
198 |
[21] |
|
POAG |
0.638 |
0.863 |
0.488 |
200 |
|
U.S Caucasian |
Control |
0.719 |
0.795 |
0.456 |
88 |
[23] |
|
POAG |
0.724 |
0.771 |
0.412 |
331 |
|
African American |
Control |
NA |
0.599 |
0.204 |
97 |
[33] |
|
POAG |
NA |
0.617 |
0.237 |
193 |
|
India |
Control |
0.695 |
0.75 |
0.32 |
105 |
[34] |
|
POAG |
0.616 |
0.83 |
0.325 |
112 |
|
Japan |
Control |
0.493 |
0.877 |
0.058 |
138 |
[30] |
|
POAG |
0.395 |
0.911 |
0.048 |
60 |
|
Southern China |
Control |
0.472 |
0.876 |
0.102 |
250 |
Present study |
|
POAG |
0.42 |
0.894 |
0.084 |
293 |
|
Northern China |
Control |
0.497 |
0.865 |
0.084 |
197 |
Present study |
POAG | 0.479 | 0.899 | 0.086 | 169 |
Allele frequencies of rs1048661 G, rs3825942 G, and rs2165241 T in POAG cases and controls among different populations were displayed in the table. In the referred studies [21,23,30,33,34] and in our present study, the SNPs were not significantly associated with POAG individually. NA: not available.