TABLE 2.
Outcome analysis of treatment effects
| Change from Baseline to 2 wks
|
Change from Baseline to 6 mos
|
||||||
|---|---|---|---|---|---|---|---|
| Measure | Baseline Mean (SD) | 2-wk Mean (SD) | 6-mo Mean (SD) | Mean, (SD) | Effect Size | Mean, (SD) | Effect Size |
| WMFT | |||||||
| Overall | 26.0 (27.5) | 18.8 (23.6) | 23.9 (26.7) | −7.3 (6.9)* | 1.56 | −1.3(9.8) | 0.18 |
| rTMS | 15.5 (13.1) | 8.7 (9.1) | 14.4 (19.5) | −6.8 (5.6)* | 1.72 | −1.2(8.6) | 0.19 |
| Sham | 35.5 (33.9) | 27.8 (29.1) | 36.3 (31.0) | −7.7(8.1)* | 1.34 | −1.4(11.9) | 0.18 |
| MAL–amount | |||||||
| Overall | 0.9 (0.6) | 2.6(1.1) | 2.1 (1.0) | 1.7 (0.9)* | 2.51 | 1.1 (0.8)* | 2.02 |
| rTMS | 1.1 (0.6) | 3.1 (1.0) | 2.3(1.1) | 2.0 (1.2)* | 2.50 | 1.2 (1.0)* | 1.66 |
| Sham | 0.8 (0.6) | 2.1(1.1) | 1.8 (1.0) | 1.3 (0.6)* | 3.20 | 1.1 (0.4)* | 3.4 |
| MAL–how well | |||||||
| Overall | 1.0 (0.6) | 2.5 (0.8) | 2.1 (0.8) | 1.4 (0.7)* | 2.86 | 1.1 (0.5)* | 3.00 |
| rTMS | 1.2 (0.7) | 2.8 (0.7) | 2.3 (0.8) | 1.6 (0.9)* | 2.64 | 1.1 (0.6)* | 2.45 |
| Sham | 0.8 (0.6) | 2.2 (0.8) | 2.0 (0.9) | 1.3 (0.6)* | 3.29 | 1.1 (0.4)* | 4.04 |
| BBT | |||||||
| Overall | 15.6 (11.9) | 18.5 (13.2) | 16.3 (13.3) | 2.9 (4.6)* | 0.90 | 1.6 (4.7) | 0.47 |
| rTMS | 15.8 (7.9) | 20.6 (9.6) | 20.3 (9.9) | 4.8 (5.3)* | 1.27 | 4.6 (2.5)* | 2.57 |
| Sham | 15.4 (15.1) | 16.6 (16.0) | 11.1 (16.1) | 1.2 (3.1) | 0.54 | −2.3 (4.0) | 0.81 |
| Motor threshold | |||||||
| Overall | 53.3 (13.9) | 51.8 (14.4) | — | −1.5(2.3)* | 0.95 | — | — |
| rTMS | 53.6 (18.3) | 50.3 (18.5) | — | −3.3 (1.9)* | 2.5 | — | — |
| Sham | 53.1 (10.6) | 53.0 (11.4) | — | −0.1 (1.9) | 0.13 | — | — |
*
P < 0.05. WMFT, Wolf Motor Function Test; BBT, Box and Block Test; MAL, Motor Activity Log.