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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: J Pineal Res. 2008 Jun 18;46(1):43–48. doi: 10.1111/j.1600-079X.2008.00607.x

Fig. 2.

Fig. 2

Effects of melatonin on oxidative stress. The figure shows malondialdehyde levels for lipid peroxidation assay from right (ipsilateral) frontal lobe 24 hrs after surgical injury. All groups subjected to SBI showed increased oxidative stress compared to sham group. Low-dose melatonin (15mg/kg) significantly attenuated the oxidative stress compared to vehicle; however, high-dose melatonin (150mg/kg) significantly increased oxidative stress compared to all other groups. (P< 0.05 is considered significant, (*), (#) and ($) indicates v/s sham and v/s vehicle and v/s 15mg/kg melatonin respectively, ANOVA p<0.001). n numbers are as follows: sham = 4; vehicle treated = 6; melatonin 15mg/kg = 8;150mg/kg = 6.