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. Author manuscript; available in PMC: 2010 Jan 1.

Published in final edited form as: J Pineal Res. 2008 Jun 18;46(1):43–48. doi: 10.1111/j.1600-079X.2008.00607.x

Fig. 4 — A: Vibrissae stimulation - paw placement test showed worsening scores in all groups subjected to SBI as compared to sham group. The 15mg/kg dose significantly improved the scores compared to vehicle group which were reversed with 150mg/kg dose. (*) and (#) indicates v/s sham and 15mg/kg melatonin respectively for P<0.05. n numbers are as follows: sham = 11; vehicle treated = 15; melatonin 5mg/kg = 8; 15mg/kg = 13; 150mg/kg = 14.

B and C: The beam walking tests on both 2.4cm (Fig. 4B) and 5 cm (Fig. 4C) diameter beams indicated that with the exception of “time spent on beam” parameter for 5cm beam, all vehicle-treated animals showed worsening parameters such as increased time taken, decreased distance traversed and lesser speed on the beams as compared to sham group. Both melatonin groups showed significant improvement in time taken on 2.4cm beam with no significant changes in other parameters. (*) and (#) indicates v/s sham and vehicle respectively. P< 0.05 is considered significant. n numbers are as follows: sham = 11 (2.4 cm beam) and 4 (5cm beam); vehicle treated = 8 (both beams); melatonin 15mg/kg = 6 (both beams); 150mg/kg = 14 (both beams).

Fig. 4 — A: Vibrissae stimulation - paw placement test showed worsening scores in all groups subjected to SBI as compared to sham group. The 15mg/kg dose significantly improved the scores compared to vehicle group which were reversed with 150mg/kg dose. (*) and (#) indicates v/s sham and 15mg/kg melatonin respectively for P<0.05. n numbers are as follows: sham = 11; vehicle treated = 15; melatonin 5mg/kg = 8; 15mg/kg = 13; 150mg/kg = 14.

B and C: The beam walking tests on both 2.4cm (Fig. 4B) and 5 cm (Fig. 4C) diameter beams indicated that with the exception of “time spent on beam” parameter for 5cm beam, all vehicle-treated animals showed worsening parameters such as increased time taken, decreased distance traversed and lesser speed on the beams as compared to sham group. Both melatonin groups showed significant improvement in time taken on 2.4cm beam with no significant changes in other parameters. (*) and (#) indicates v/s sham and vehicle respectively. P< 0.05 is considered significant. n numbers are as follows: sham = 11 (2.4 cm beam) and 4 (5cm beam); vehicle treated = 8 (both beams); melatonin 15mg/kg = 6 (both beams); 150mg/kg = 14 (both beams).