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. Author manuscript; available in PMC: 2009 Dec 25.
Published in final edited form as: J Med Chem. 2008 Dec 25;51(24):7866–7881. doi: 10.1021/jm800913d

Table 2.

[125I]Ioxy Binding Data for ortho- and para-d Oxide-bridged Phenylmorphansa.

graphic file with name nihms78004f14.jpg
Ki (nM ± SD)
Cmpd # R1 R2 R3 μ d κ
46 Me OH H 8000 ± 406 3430 ± 92 4820 ± 198
51 Phenethyl OH H 560 ± 27 2840 ± 56 200 ± 3
47 Me H OH 2930 ± 203 2780 ± 54 620 ± 21
52 Phenethyl H OH 1220 ± 56 2530 ± 76 560 ± 25
a

Assays were conducted using CHO cells, which were stably transfected and express the μ-, δ- or κ-opioid receptors respectively, as described previously.19 All results n=3.