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Treatment of orthotopic E3LZ10.7 xenografts with IPI-269609. A, treatment with IPI-269609 (20 mg/kg/d p.o.) for 30 d did not affect the growth of orthotopic E3LZ10.7 xenografts. B, H&E stainings of orthotopic E3LZ10.7 treated with IPI-269609 (i) or solvent only (ii ). C, examples of histologies of E3LZ10.7 metastases to lymph node (i) and spleen (ii ); H&E staining.
