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Application of IPI-269609 caused significant down-regulation of the Hedgehog target gene Ptch1 at the mRNA level in vivo in E3LZ10.7 xenografts (A), which was accompanied by reduction of cancer cells with high ALDH activity as visualized by immunohistochemistry (B). ALDH-positive cells were quantified using Frida analysis software (C; *, P < 0.05).
